In the micro level, at the detail, all things matter, so to speak. Not the quantum micro level, mind, that's a different story altogether. The micro level of laptops and GMATs, cars and nails, dogs and humans.
At the macro level, however, nothing matters. How could it? At the macro level, there is no context for anything to matter. Everything and anything is insignificant among the vastness of infinite multiverses.
The human dilemma seems to be in reconciling, as usual. Problem is, there is no point of reference, hence the sad rich and the joyous poor, the Suicide Bomber and the Playboy Playmate. Zen and the art of searching for points of reference. One who writes it must be God! :)
But why make it so complex when we are as adept at finding temporary references? At that point, Philosophy (and perhaps Higher Physics?!;)) seem to become refuges for the invalids. Make it easy... want it not? Strive not. Shout that 'I DON'T WANT IT' and the fakement is there to see. Want it? Go for it, who's stopping you? But of course, there's that thorn of contention... just a slight mental tingle, but so easily ignorable.
Or are you still going to blame the Point of Reference?